Wholesale Best Price Water Soluble Dihydroberberine 98% Powder

• CAS No.: 483-15-8
• Formula: C20h19no4
• EINECS: N/a
• Resource: Natural
• Product Name: Dihydroberberine Powder
• Character: Light Yellow
• Model NO.: N/A
• Shelf Life: 2 Years
• Storage Condition: Sealed in Cool and Dry Place, Guard Against Damp.
• Trasport Method: by Air or by Sea.
• Transport Package: 25kg/Barrel. Inner PE Bag, Outer Cardboard Box.
• Specification: Powder
• Trademark: N/A
• Origin: China
• HS Code: 2103909000
• Production Capacity: 10000kg/Year

Product Description

Product Description

Product Description	Dihydroberberine inhibits human Ether-related gene (hERG) channels and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG.Dihydroberberine possesses anti-inflammatory, anti-atherosclerotic, hypolipidemic and antitumor activities. Dihydroberberine yellow crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Berberis. UsesDihydroberberine has anti-myocardial ischemia and arrhythmia. Dihydroberberine (DHB), a hydrogenated derivative of BBR, has been shown to be highly effective in vivo against a number of metabolic diseases and has a favorable safety profile.
Function	DHB exerts its uric acid-lowering effect by inhibiting the activation of XOD, URAT1, GLUT9, and NLRP3 inflammatory vesicles in the kidneys, and is renoprotective in addition to being antihyperuricemic. The treatment of DHB had a protective effect on renal function. These results suggest that DHB ameliorates renal injury and has a nephroprotective effect in HUA mice. DHB showed XOD enzyme inhibition in a concentration-dependent manner.DHB significantly inhibited XOD activity (Figure 4D). This result suggests that DHB has an inhibitory effect on XOD. Treatment with DHB was effective in ameliorating PO/HX-induced renal inflammation. DHB showed the ability to inhibit XOD activity both in vitro and in vivo. And the treatment of DHB also showed significant inhibition of renal URAT1 and GLUT9 levels. Thus, DHB was able to reduce urate formation by inhibiting hepatic XOD while down-regulating renal URAT1 and GLUT9 to enhance urate excretion, suggesting a dual anti-hyperuricemic effect. In addition, the mechanism by which DHB exerts its renoprotective effects was found to be through the inhibition of NLRP3 inflammasome activation to attenuate renal inflammation and dysfunction.
Application	Health Care Products, Food, Daily Necessities, Cosmetics, Functional Drink
Application Form	Lotion, Paste, Tablet, Capsule, Granules

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		Ginsenosides 1-80% HPLC
		Total rare ginsenosides>20% HPLC (Rk2+ (S)-Rg3+ (R)-Rg3+ (S)-Rh2+ (R)-Rh2+ Rg5+ Rk1+Rk3+ (S)-Rh1+ (R)-Rh1+ Rh3+ Rh4 + (S)-aPPT+ (R)-aPPT+ (S)-aPPD+ (R)-aPPD)
		Eleutherosides (B+E) 0.8-1.2%
Mushroom Series		β-Glucan 1-10%; Polysaccharides 30%; Triterpene 1-30%
		Polysaccharides 30%
		β-Glucan 1-10%; Polysaccharides 30%
		Polysaccharides 30%
		Polysaccharides 30%; Triterpene 1-10%
		Adenosine 0.22%; Mannitol 8%
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Organic Products		Total Acid 5%
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		Ratio Extract; Flavone 3%
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Fruit Series		4:1
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Herbal Extract		SAC 0.1-4%; Polyphenol 1-3%
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		DNJ 0.8-5%
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		20-40% HPLC, Nature origin
		Theaflavin≥5%

FAQ

Q1: What's the difference between herb extract and powder?
A: The extract is a concentrated powder form of raw material. The herb extract's procedure flow is wash, extraction, concentration, purification, drying, grinding, sieving, package. The herb powder is just a powder form of the herb. The procedure flow is wash, drying, grinding, sieving, package.

Q2: What's the extract solvent used in the procedure?
A: The extract solvent is always depending on the active ingredient in the raw material, regulation and customers' requirement. The solvents mostly used for extraction are water and ethanol. Even the solvent other than water used in the procedure, the solvent residue in the extract product also can conform with ICH Q3CR5.

Q3: Is there any other ingredient used in the product?
A: It depends. For product which is hard to be dried, we need to add some maltodextrin into the extraction solution before drying. The maltodextrin we used is food-class carrier, from non-GMO corn. We can share customer with the ingredient composition table.

Q4: How to make sure the quality of the product?
A: Firstly, every batch finish product must be tested and qualified before delivery. We can send a specification sheet or CoA for confirmation. The HPLC chromatography graph also can be provided. Secondly, we can provide pre-ship sample to customer for quality confirmation. 

Q5: Can you develop a new product for us?
A: Yes, we can. We have independent R&D dept, who is able to update the procedure parameters of our main products and develop the procedure of new product. For more information, please contact us directly.

Q6: Can you offer this in capsules or tablets as well?
A: Yes, we have related equipment for preparation of finish product, like tablet, capsule and granule. Kindly contact with us for details.

Q7: What is the MOQ?
A: For most of the products we already have in stock, the MOQ is 1kg. If the product is a new specification and need to be produced from raw material, the MOQ depends.

Q8: Is there any discount?
A: Yes, for larger quantity or better payment period, we can support with better price.

Q9: How about delivery time?
A: For most products, the product can be sent out from factory in 5days. If we don't have inventory, the product need to produced from raw material, the ordinary period is 20-25days.

Q10: How do you treat with quality complaint?
A: We will always be responsible for the quality of our products. If there's a complaint, we will first assist customers to solve the most direct needs.
Secondly, we have SOP for quality complaint. QA will investigate the problem, after that we'll give customer a formal feedback about the cause of the quality issue and related precautions for this problem.